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Ruepp, A. ; Zollner, A.* ; Maier, D.* ; Albermann, K.* ; Hani, J.* ; Mokrejs, M. ; Tetko, I.V. ; Güldener, U. ; Mannhaupt, G. ; Münsterkötter, M. ; Mewes, H.-W.

The FunCat, a functional annotation scheme for systematic classification of proteins from whole genomes.

Nucleic Acids Res. 32, 5539-5545 (2004)
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In this paper, we present the Functional Catalogue (FunCat), a hierarchically structured, organism-independent, flexible and scalable controlled classification system enabling the functional description of proteins from any organism. FunCat has been applied for the manual annotation of prokaryotes, fungi, plants and animals. We describe how FunCat is implemented as a highly efficient and robust tool for the manual and automatic annotation of genomic sequences. Owing to its hierarchical architecture, FunCat has also proved to be useful for many subsequent downstream bioinformatic applications. This is illustrated by the analysis of large-scale experiments from various investigations in transcriptomics and proteomics, where FunCat was used to project experimental data into functional units, as 'gold standard' for functional classification methods, and also served to compare the significance of different experimental methods. Over the last decade, the FunCat has been established as a robust and stable annotation scheme that offers both, meaningful and manageable functional classification as well as ease of perception.
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Publication type Article: Journal article
Document type Scientific Article
Keywords SACCHAROMYCES-CEREVISIAE GENOME; ESCHERICHIA-COLI; SEQUENCE; DATABASE; NETWORK; COMPLEXES; MOTIFS; MIPS
Language english
Publication Year 2004
HGF-reported in Year 0
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Journal Nucleic Acids Research
Quellenangaben Volume: 32, Issue: 18, Pages: 5539-5545 Article Number: , Supplement: ,
Publisher Oxford University Press
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)
POF-Topic(s) 30505 - New Technologies for Biomedical Discoveries
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-503700-001
PubMed ID 15486203
DOI 10.1093/nar/gkh894
WOS ID 000224704200027
Scopus ID 9144257282
Erfassungsdatum 2004-12-31
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