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Open Access Green as soon as Postprint is submitted to ZB.
Establishment and characterization of C-type RNA virus-producing cell lines from radiation-induced murine osteosarcomas.
J. Cancer Res. Clin. Oncol. 94, 149-162 (1979)
Eight cell lines were established from murine osteosarcomas induced in vivo with the radionuclides 224Ra and 227Th. They have been compared by light and electron microscopy, by karyology, and by their growth properties. The morphology, the growth pattern, and the ability to induce tumors in mice indicate that five of them are tumor cell lines. Chromosome studies demonstrated that the five cell lines have marker chromosomes. The other cell lines only showed some criteria generally used to score for transformation of fibroblasts and they may be derived from stromal cells. All cell lines release virus particles in the culture fluid which have the typical properties of RNA tumor viruses. They possess C-type morphology, a density of 1.16--1.18 g/cm3, a 60--70 S RNA, a RNA dependent DNA polymerase and they induce syncytia in rat XC cells. The possible significance of these virus particles in radiation osteosarcomagenesis is discussed.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
C-type Rna Virus ; Cell Line ; Mice ; Radiation-induced Osteosarcoma
ISSN (print) / ISBN
0171-5216
e-ISSN
1432-1335
Quellenangaben
Volume: 94,
Issue: 2,
Pages: 149-162
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed