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Zeidler, R. ; Albermann, K.* ; Lang, S.*

Nicotine and apoptosis.

Apoptosis 12, 1927-1943 (2007)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Cigarette smoking is associated with a plethora of different diseases. Nicotine is the addictive component of cigarette but also acts onto cells of the non-neuronal system, including immune effector cells. Although nicotine itself is usually not referred to as a carcinogen, there is ongoing debate whether nicotine functions as a 'tumor enhancer.' By binding to nicotinic acetylcholine receptors, nicotine deregulates essential biological processes like angiogenesis, apoptosis, and cell-mediated immunity. Apoptosis plays critical roles in a wide variety of physiologic processes during fetal development and in adult tissue and is also a fundamental aspect of the biology of malignant diseases. This review provides an overlook how nicotine influences apoptotic processes and is thus directly involved in the etiology of pathological conditions like cancer and obstructive diseases.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2007
HGF-reported in Year 0
ISSN (print) / ISBN 1360-8185
e-ISSN 1573-675X
Journal Apoptosis
Quellenangaben Volume: 12, Issue: 11, Pages: 1927-1943 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
PubMed ID 17846896
Erfassungsdatum 2007-12-31