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Then, C. ; Kowall, B.* ; Lechner, A. ; Meisinger, C. ; Heier, M. ; Koenig, W.* ; Peters, A. ; Thiery, J.* ; Rathmann, W.* ; Seissler, J.

Plasma MR-proANP levels are associated with carotid intima-media thickness in the general community: The KORA F4 study.

Atherosclerosis 230, 235-241 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE: Subjects with metabolic syndrome (MetS) and individuals with type 2 diabetes are at high risk for vascular complications. Hormones acting on vascular endothelium may be involved in the atherogenic process associated with metabolic disorders. The objective of this study was to determine the correlation of pro-atrial natriuretic hormone (proANP) with the presence of subclinical atherosclerosis. METHODS: In 1272 subjects participating in the KORA F4 study, we determined plasma levels of mid-regional proANP (MR-proANP) and the intima-media thickness (IMT) of the carotid artery. We used logistic regression models to investigate the relation of MR-proANP with components of MetS and IMT. RESULTS: In multiple adjusted regression models, MR-proANP levels were inversely associated with MetS (OR = 0.66, 95% CI 0.47-0.93), central obesity (OR = 0.67, 95% CI 0.46-0.96), raised triglyceride levels (OR = 0.53, 95% CI 0.37-0.77), prediabetes (OR = 0.62, 95%, CI 0.44-0.87) and type 2 diabetes (OR = 0.55, 95% CI 0.35-0.88) when comparing the top quartile vs. the lower three quartiles. Furthermore, there was an inverse relationship between MR-proANP and IMT. After adjustment for traditional cardiovascular risk markers, individuals with high MR-proANP plasma levels in the top quartile (Q4) had significantly lower IMT values (Q4 vs. Q1-Q3: β -0.0178, 95% CI -0.0344; -0.0013). CONCLUSIONS: In this population-based study, high plasma concentrations of MR-proANP were significantly associated with a lower incidence of MetS components and lower measures of early atherosclerosis. The data suggest a link between MR-proANP levels and the development of vascular complications.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Diabetes; Intima-media thickness; Metabolic syndrome; MR-proANP; Natriuretic peptide; Vasoactive hormones; Atrial-natriuretic-peptide ; N-terminal-proatrial ; Heart-disease Risk ; Metabolic Syndrome ; Cardiovascular Events ; Vascular Function ; Diabetic-patients ; Adipose-tissue ; Probnp Levels ; Population
ISSN (print) / ISBN 0021-9150
e-ISSN 1879-1484
Journal Atherosclerosis
Quellenangaben Volume: 230, Issue: 2, Pages: 235-241 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Epidemiology (EPI)