Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
New EVA Application
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
Publ. Version/Full Text
DOI
 |
Closed |
Open Access Green as soon as Postprint is submitted to ZB.
Novel temperature-sensitive liposomes with prolonged circulation time.
Clin. Cancer Res. 10, 2168-2178 (2004)
Hyperthermia increases the efficiency of various chemotherapeutic drugs and is administered as an adjunct to chemotherapy for the treatment of cancer patients. The temperature-dependent effect can be strongly increased by the use of temperature-sensitive liposomes in combination with regional hyperthermia, which specifically releases the entrapped drug in the heated tumor tissue. The novel lipid 1.2-dipaimitoyl-sn-glycero-3-phosphoglyceroglycerol (DPPGOG), which is closely related to the naturally occurring 1.2-dipalmitoyi-sn-glycero-3-phosphoglycerol, in combination with 1.2-dipalmitoyl-sn-glycero-3-phosphocholine and 1.2-distearoyi-sn-glycero-3-phosphocholine provides long-circulating temperature-sensitive liposomes with favorable properties under mildly hyperthermic conditions (41-42degreesC). DPPGOG facilitates temperature-triggered drug release from these liposomes (diameter, 175 nm) and leads to a substantially prolonged plasma half-life for the encapsulated drug with t(1/2) = 9.6 h in hamsters and t(1/2) = 5.0 h in rats. Quantitative fluorescence microscopy of amelanotic melanoma grown in the transparent dorsal skin fold chamber of hamsters demonstrated a favorable drug accumulation in heated tissue after i.v. application of these liposomes (42degreesC for 1 h). The mean area under the curve for tissue drug concentration was increased by more than sixfold by application of the new liposomes compared with nonliposomal drug delivery. In summary, we present a new DPPGOG-based liposomal formulation enabling long circulation time combined with fast and efficient drug release under mild hyperthermia. This adds positively to the results with lipid-grafted polyethylenglycol used thus far in temperature-sensitive liposomes and widens the possibilities for clinical applications.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
6.511
0.000
136
199
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
STERICALLY STABILIZED LIPOSOMES; TUMOR XENOGRAFT MODEL; THERMOSENSITIVE LIPOSOMES; LOCAL HYPERTHERMIA; REGIONAL HYPERTHERMIA; TARGETING CHEMOTHERAPY; PHOSPHOLIPID-VESICLES; POLYETHYLENE-GLYCOL; ENHANCED DELIVERY; SOLID TUMORS
Language
english
Publication Year
2004
HGF-reported in Year
0
ISSN (print) / ISBN
1078-0432
e-ISSN
1557-3265
Journal
Clinical Cancer Research
Quellenangaben
Volume: 10,
Issue: 6,
Pages: 2168-2178
Publisher
American Association for Cancer Research (AACR)
Reviewing status
Peer reviewed
Institute(s)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-521100-001
Scopus ID
1642392535
Erfassungsdatum
2004-05-05