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Long-term experiment to study the development, interaction and influencing factors of DEXA parameters.
Mamm. Genome 24, 376-388 (2013)
Dual-energy X-ray absorption (DEXA) is commonly used to measure bone mineral density (BMD), bone mineral content (BMC), and body composition data (fat mass and lean mass) for phenotype assessment in mice. We were interested in the long-term development of BMD, BMC, lean mass, and fat mass of mice, also taking into account sex and genetic background. The dataset was used to analyze correlations among the different parameters. We analyzed males and females from inbred strains C3HeB/FeJ and C57BL/6J, starting from 42 until 528 days of age. To evaluate the effect of husbandry systems, we repeated a part of the study in a second facility with a different caging system. We also assessed different DEXA settings and repeatability of the scans. The results of this study were used to draw conclusions for the use of DEXA analysis in mouse phenotyping approaches.
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Times Cited
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2.419
0.690
4
4
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
X-ray Absorptiometry ; Future Perspectives ; Body-composition ; Bone-density ; Genome-wide ; Mice ; Mouse ; Mutagenesis
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
0938-8990
e-ISSN
1432-1777
Journal
Mammalian Genome
Quellenangaben
Volume: 24,
Issue: 9-10,
Pages: 376-388
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)
POF-Topic(s)
30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-500600-003
G-500600-001
G-500600-002
G-500600-001
G-500600-002
PubMed ID
24096374
WOS ID
WOS:000325616000004
Scopus ID
84886883373
Erfassungsdatum
2013-10-07