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Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
Hum. Mol. Genet. 16, 1821-1827 (2007)
Publ. Version/Full Text Volltext
DOI
PMC
Single-nucleotide polymorphisms within the BAT1-NFKBIL1-LTA genomic region (6p21.3) and the LGALS2 gene (22q13.1), encoding a regulator for lymphotoxin-alpha, the product of the LTA gene, have been reported to be linked with the risk of myocardial infarction in Japanese. We employed nine polymorphisms from the BAT1-NFKBIL1-LTA region and one polymorphism from the LGALS2 gene, and investigated whether such associations were also present in Europeans. The study included 3657 patients with myocardial infarction and 1211 control individuals with angiographically normal coronary arteries. Minor homozygous genotypes of polymorphisms in BAT1 (rs2239527, -23C/G), NFKBIL1 (rs2071592, -63T/A) and LTA (rs1800683, -162G/A; rs909253, 252G/A; rs1041981, Thr26Asn) were associated with moderately protective effects against myocardial infarction (P
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
LYMPHOTOXIN-ALPHA GENE; SINGLE-NUCLEOTIDE POLYMORPHISMS; HISTOCOMPATIBILITY COMPLEX; SUSCEPTIBILITY LOCUS; HAPLOTYPE; DISEASE; ATHEROSCLEROSIS; PROMOTER; POPULATION; JAPANESE
ISSN (print) / ISBN
0964-6906
e-ISSN
1460-2083
Journal
Human Molecular Genetics
Quellenangaben
Volume: 16,
Issue: 15,
Pages: 1821-1827
Publisher
Oxford University Press
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Reviewing status
Peer reviewed