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Azimzadeh, O. ; Atkinson, M.J. ; Tapio, S.

Proteomics in radiation research: Present status and future perspectives.

Radiat. Environ. Biophys. 53, 31-38 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Rapidly developing postgenome research has made proteins an attractive target for biological analysis. The well-established term of proteome is defined as the complete set of proteins expressed in a given cell, tissue or organism. Unlike the genome, a proteome is rapidly changing as it tends to adapt to microenvironmental signals. The systematic analysis of the proteome at a given time and state is referred to as proteomics. This technique provides information on the molecular and cellular mechanisms that regulate physiology and pathophysiology of the cell. Applications of proteome profiling in radiation research are increasing. However, the large-scale proteomics data sets generated need to be integrated into other fields of radiation biology to facilitate the interpretation of radiation-induced cellular and tissue effects. The aim of this review is to introduce the most recent developments in the field of radiation proteomics.
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Publication type Article: Journal article
Document type Review
Keywords Ionizing radiation; Proteomics; Oxidative stress; Mitochondria; DNA damage response; Posttranslational modification; Biomarker; Coded Protein Labels; Dna-damage Response; Ionizing-radiation; Oxidative Stress; Gamma-radiation; Posttranslational Modifications; Mitochondrial Proteins; Shotgun Proteomics; Plasma Citrulline; Enterocyte Mass
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 53, Issue: 1, Pages: 31-38 Article Number: , Supplement: ,
Publisher Springer
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Radiation Sciences
PSP Element(s) G-500200-001
PubMed ID 24105449
DOI 10.1007/s00411-013-0495-4
WOS ID WOS:000331977300002
Scopus ID 84895926485
Erfassungsdatum 2013-10-16
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