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Eick, D. ; Geyer, M.*

The RNA polymerase II Carboxy-Terminal Domain (CTD) code.

Chem. Rev. 113, 8456-8490 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same nucleic acid-based universal code for the maintenance and inheritance of genetic information. All life on earth probably started with a common ancestral cell approximately 4 billion years ago. Today, a huge diversity of organisms live on Earth, many of them still at the evolutionary stage of unicellular organisms, while others are life forms of high complexity with large cell numbers. The development of this diversity was driven by evolution, a process assuring survival and adaption of life to new environmental challenges. While the first evolutionary processes were probably very simple genetic changes, these processes gradually became more sophisticated with the development of higher eukaryotes. The remaining major part of the genome, including all coding genes, is transcribed by RNAPII. It was first assumed that RNAPII transcription might be limited to genomic loci that give rise to messenger RNA (mRNA) or other stable transcripts.
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Publication type Article: Journal article
Document type Review
Keywords Pre-messenger-rna ; Bromodomain Protein Brd4 ; Serine 2 Phosphorylation ; Transcription In-vivo ; Recruits P-tefb ; Capping Enzyme Recruitment ; Histone H3k36 Methylation ; Gene-specific Requirement ; Cyclin-dependent Kinase ; Tata-binding Protein
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0009-2665
e-ISSN 1520-6890
Journal Chemical Reviews
Quellenangaben Volume: 113, Issue: 11, Pages: 8456-8490 Article Number: , Supplement: ,
Publisher American Chemical Society (ACS)
Reviewing status Peer reviewed
Institute(s) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501490-001
PubMed ID 23952966
DOI 10.1021/cr400071f
WOS ID WOS:000327103200007
Scopus ID 84888991588
Erfassungsdatum 2013-10-16
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