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Open Access Green as soon as Postprint is submitted to ZB.
Ligand-independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice.
Exp. Dermatol. 22, 667-669 (2013)
The epidermal growth factor receptor (EGFR) system is an established regulator of the development and homeostasis of the hair follicle and interfollicular epidermis. Here, we evaluated EGFR actions on the sebaceous glands (SGs) by employing Dsk5 mice, a mutant line in which the EGFR is constitutively activated in a ligand-independent manner. Compared to control littermates, Dsk5 mice showed increased sebum levels and enlarged SGs, which contained a higher number of cells and showed stronger proliferation. c-myc transcript levels were increased in Dsk5 skin, suggesting that c-myc mediates the proliferative stimuli of the EGFR in the SG. Analysis of differentiation markers revealed deregulated expression of Scd1 and Scd3, indicating that sebaceous lipogenesis is affected in Dsk5 mice. In conclusion, our study indicates that the EGFR is an important regulator of presebocyte proliferation, contributing to the final cell number, to the size and to the lipid output of SGs.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Epidermal growth factor receptor; Mouse; Sebaceous gland; Sebum; Melanocyte-stimulating Hormone ; Inhibits Melanin Synthesis ; C-myc ; Cell-migration ; Stem-cells ; In-vitro ; Skin ; Expression ; Chemotaxis ; Differentiation
ISSN (print) / ISBN
0906-6705
e-ISSN
1600-0625
Journal
Experimental Dermatology
Quellenangaben
Volume: 22,
Issue: 10,
Pages: 667-669
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Experimental Genetics (IEG)