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Targeting c-MYC with T-cells.
PLoS ONE 8:e77375 (2013)
Over-expression of the proto-oncogene c-MYC is frequently observed in a variety of tumors and is a hallmark of Burkitt´s lymphoma. The fact that many tumors are oncogene-addicted to c-MYC, renders c-MYC a powerful target for anti-tumor therapy. Using a xenogenic vaccination strategy by immunizing C57BL/6 mice with human c-MYC protein or non-homologous peptides, we show that the human c-MYC protein, despite its high homology between mouse and man, contains several immunogenic epitopes presented in the context of murine H2(b) haplotype. We identified an MHC class II-restricted CD4(+) T-cell epitope and therein an MHC class I-restricted CD8(+) T-cell epitope (SSPQGSPEPL) that, after prime/boost immunization, protected up to 25% of mice against a lethal lymphoma challenge. Lymphoma-rejecting animals contained MHC multimer-binding CD8(+) cell within the peripheral blood and displayed in vivo cytolytic activity with specificity for SSPQGSPEPL. Taken together these data suggest that oncogenic c-MYC can be targeted with specific T-cells.
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3.730
1.063
9
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Oncogene Inactivation ; Tissue Microarrays ; Burkitts-lymphoma ; Dendritic Cells ; Cancer ; Antigen ; Immunotherapy ; Differentiation ; Mutations ; Tumors
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
1932-6203
Journal
PLoS ONE
Quellenangaben
Volume: 8,
Issue: 10,
Article Number: e77375
Publisher
Public Library of Science (PLoS)
Publishing Place
Lawrence, Kan.
Reviewing status
Peer reviewed
Institute(s)
CCG Pediatric Tumor Immunology (AGV-KPT)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-520900-001
G-501400-006
G-501400-006
PubMed ID
24130880
WOS ID
WOS:000325814200084
Scopus ID
84885399823
Erfassungsdatum
2013-10-23