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Buchholz, V.R.* ; Gräf, P.* ; Busch, D.H.

The smallest unit: Effector and memory CD8+ T cell differentiation on the single cell level.

Front. Immunol. 4:31 (2013)
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CD8(+) T cell immune responses provide immediate protection against primary infection and durable memory capable of rapidly fighting off re-infection. Immediate protection and lasting memory are implemented by phenotypically and functionally distinct T cell subsets. While it is now widely accepted that these diverge from a common source of naïve T cells (T(n)), the developmental relation and succession of effector and memory T cell subsets is still under intense debate. Recently, a distinct memory T cell subset has been suggested to possess stem cell-like features, sparking the hope to harness its capacity for self-renewal and diversification for successful therapy of chronic infections or malignant diseases. In this review we highlight current developmental models of memory generation, T cell subset diversification and T cell stemness. We discuss the importance of single cell monitoring techniques for adequately mapping these developmental processes and take a brief look at signaling components active in the putative stem cell-like memory T cell compartment.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2013
HGF-reported in Year 0
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 4, Issue: , Pages: , Article Number: 31 Supplement: ,
Publisher Frontiers
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
Institute of Virology (VIRO)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501790-003
G-520100-001
PubMed ID 23424063
DOI 10.3389/fimmu.2013.00031
Erfassungsdatum 2013-10-30
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