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Sim, X.* ; Jensen, R.A.* ; Ikram, M.K.* ; Cotch, M.F.* ; Li, X.* ; MacGregor, S.* ; Xie, J.* ; Smith, A.V.* ; Boerwinkle, E.* ; Mitchell, P.* ; Klein, R.* ; Klein, B.E.* ; Glazer, N.L.* ; Lumley, T.* ; McKnight, B.* ; Psaty, B.M.* ; de Jong, P.T.* ; Hofman, A.* ; Rivadeneira, F.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; Aspelund, T.* ; Eiriksdottir, G.* ; Harris, T.B.* ; Jonasson, F.* ; Launer, L.J.* ; Wellcome Trust Case Control Consortium 2 (WTCCC2) (*) ; Attia, J.* ; Baird, P.N.* ; Harrap, S.* ; Holliday, E.G.* ; Inouye, M.* ; Rochtchina, E.* ; Scott, R.J.* ; Viswanathan, A.* ; Global BPgen Consortium (Eyheramendy, S. ; Döring, A. ; Gieger, C. ; Illig, T. ; Meitinger, T. ; Pfeufer, A. ; Wichmann, H.-E.) ; Li, G.* ; Smith, N.L.* ; Wiggins, K.L.* ; Kuo, J.Z.* ; Taylor, K.D.* ; Hewitt, A.W.* ; Martin, N.G.* ; Montgomery, G.W.* ; Sun, C.* ; Young, T.L.* ; Mackey, D.A.* ; van Zuydam, N.* ; Doney, A.S.* ; Palmer, C.N.* ; Morris, A.D.* ; Rotter, J.I.* ; Tai, E.S.* ; Gudnason, V.* ; Vingerling, J.R.* ; Siscovick, D.S.* ; Wang, J.J.* ; Wong, T.Y.*

Genetic loci for retinal arteriolar microcirculation.

PLoS ONE 8:e65804 (2013)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value <5×10(-8). This variant was replicated in an additional 3,939 individuals of European ancestry from the Australian Twins Study and Multi-Ethnic Study of Atherosclerosis (rs2194025, P-value = 2.11×10(-12) in combined meta-analysis of discovery and replication cohorts). In independent studies of modest sample sizes, no significant association was found between this variant and clinical outcomes including coronary artery disease, stroke, myocardial infarction or hypertension. In conclusion, we found one novel loci which underlie genetic variation in microvasculature which may be relevant to vascular disease. The relevance of these findings to clinical outcomes remains to be determined.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 8, Issue: 6, Pages: , Article Number: e65804 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Institute of Genetic Epidemiology (IGE)
Research Unit Molecular Epidemiology (AME)
Institute of Human Genetics (IHG)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)