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Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin and C-reactive protein levels in response to 4-week very-high-fructose or -glucose diets.
Eur. J. Clin. Nutr. 68, 97-100 (2014)
Background/objectives:High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders. Especially, high-fructose intake is regarded as potentially harmful to cardiometabolic health. It may cause not only weight gain but also low-grade inflammation, which represents an independent risk factor for developing type 2 diabetes and cardiovascular disease. In particular, fructose has been suggested to induce plasminogen activator inhibitor-1 (PAI-1) expression in the liver and to increase circulating inflammatory cytokines. We therefore aimed to investigate, whether high-fructose diet has an impact on PAI-1, monocyte chemoattractant protein-1 (MCP-1), e-selectin and C-reactive protein (CRP) concentrations in healthy humans.Subjects/methods:We studied 20 participants (12 males and 8 females) of the TUebingen FRuctose Or Glucose study. This is an exploratory, parallel, prospective, randomized, single-blinded, outpatient, hypercaloric, intervention study. The participants had a mean age of 30.9±2.1 years and a mean body mass index of 26.0±0.5 kg/m(2) and they received 150 g of either fructose or glucose per day for 4 weeks.Results:There were neither significant changes of PAI-1, MCP-1, e-selectin and CRP after fructose (n=10) and glucose (n=10) intervention nor treatment effects (all P>0.2). Moreover, we did not observe longitudinal associations of the inflammatory parameters with triglycerides, liver fat, visceral fat and body weight in the fructose group.Conclusions:Temporary high-fructose intake does not seem to cause inflammation in apparently healthy people in this secondary analysis of a small feeding trial.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Crp ; E-selectin ; Fructose ; Inflammation ; Mcp-1 ; Pai-1; Sweetened Beverages; Healthy-subjects; Blood-pressure; Disease; Risk; Metabolism; Sugar; Fat; Men; Inflammation
ISSN (print) / ISBN
0954-3007
e-ISSN
1476-5640
Quellenangaben
Volume: 68,
Issue: 1,
Pages: 97-100
Publisher
Nature Publishing Group
Non-patent literature
Publications
Reviewing status
Peer reviewed