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Hampel, R. ; Rückerl, R. ; Yli-Tuomi, T.* ; Breitner-Busch, S. ; Lanki, T.* ; Kraus, U. ; Cyrys, J. ; Belcredi, P. ; Brüske, I. ; Laitinen, T.M.* ; Timonen, K.* ; Wichmann, H.-E. ; Peters, A. ; Schneider, A.E.

Impact of personally measured pollutants on cardiac function.

Int. J. Hyg. Environ. Health 217, 460-464 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Epidemiological studies have shown associations between ambient air pollution and changes in heart rate variability (HRV). However, studies using personal air pollution measurements, especially with exposure averages <24h, are still rare. Between February and March 2008 HRV data as well as personal exposure to particulate matter <2.5μm (PM2.5), and particle number concentrations (PNC) were collected in five volunteers for up to 8.3h on a 5min resolution. Information about the participant's whereabouts was also collected. Mixed models were used to analyze concurrent and up to 30min delayed effects of air pollutants as well as being in traffic on 5min-averages of heart rate (HR), high and low frequency power (HF and LF), standard deviation of all normal-to-normal intervals (SDNN), and the root mean square of successive interval differences (RMSSD). Results are presented as %-change from the mean per increase in interquartile range of air pollutant. In total, 474 5-min segments were available for analysis. We observed concurrent and delayed reductions in SDNN of about 0.8-1.0% in association with a 5.4μg/m(3) increase in PM2.5. However, being in traffic by car led to an increase of about 20% 10-14min and 15-19min later. An increase in PM2.5 or PNC was associated with lagged decreases for RMSSD and HF. We detected concurrent reductions in RMSSD (-17.6% [95%-confidence interval: 29.1; -4.3]) when being in traffic by bike/foot. Being in traffic by car was associated with an immediate reduction in LF while more delayed increases in LF were observed when being in traffic by bike/foot. Air pollution and traffic effects on HR were less consistent. These rapid changes in HRV within 30min might be mediated by the autonomic nervous system in response to direct reflexes from receptors in the lungs.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Epidemiology ; Heart Rate Variability ; Personal Air Pollution Measurements ; Traffic ; Ultrafine Particles; Heart-rate-variability; Particulate Matter; Ventricular-arrhythmias; Myocardial-infarction; Pm2.5 Exposure; Air-pollution; Association; Disease; Fine
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1438-4639
e-ISSN 1618-131X
Journal International Journal of Hygiene and Environmental Health
Quellenangaben Volume: 217, Issue: 4-5, Pages: 460-464 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Amsterdam ; Boston, Mass. ; London ; New York, NY ; Oxford ; Paris ; Philadelphia, Pa. ; San Diego, Calif. ; St. Louis, Mo. ; München
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-001
G-504000-004
G-503900-001
PubMed ID 24231411
DOI 10.1016/j.ijheh.2013.09.002
WOS ID WOS:000335113500005
Scopus ID 84897045969
Erfassungsdatum 2013-11-19
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