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Open Access Green as soon as Postprint is submitted to ZB.
Have advanced research technologies made real impact on respiratory medicine?
Respirology 15, 876-880 (2010)
Tremendous sophistication in our ability to detect, measure and manipulate the genes and proteins involved in lung disease has provided unique insights to the pathobiology of a number of lung disorders affecting humans today. Gene array analysis and genetic manipulation of animals have helped to identify novel pathways and their potential role in disease initiation and progression. Proteomics is a relatively novel tool in molecular research in respiratory medicine. Silencing gene expression by using small interfering RNA may, sooner than later, become part of novel therapies. Despite the excitement, to date, there has been little direct impact on therapeutic interventions available to clinicians. However, the rapidity with which these early data have accumulated, and the expected advances in bioinformatics and systems biology, should bring forward tangible therapeutic benefits for many acute and chronic lung diseases within the next ten years.
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Publication type
Article: Journal article
Document type
Review
Keywords
Proteomics; siRNA; Gene transfer; Gene array; Biomarker
ISSN (print) / ISBN
1323-7799
e-ISSN
1440-1843
Journal
Respirology
Quellenangaben
Volume: 15,
Issue: 6,
Pages: 876-880
Publisher
Wiley
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)