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Deeg, C.A.* ; Pompetzki, D.* ; Raith, A.J.* ; Hauck, S.M. ; Amann, B.* ; Suppmann, S. ; Goebel, T.W.* ; Olazabal, U. ; Gerhards, H.* ; Reese, S.* ; Stangassinger, M.* ; Kaspers, B.* ; Ueffing, M.

Identification and functional validation of novel autoantigens in equine uveitis.

Mol. Cell. Proteomics 5, 1462-1470 (2006)
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The development, progression, and recurrence of autoimmune diseases are frequently driven by a group of participatory autoantigens. We identified and characterized novel autoantigens by analyzing the autoantibody binding pattern from horses affected by spontaneous equine recurrent uveitis to the retinal proteome. Cellular retinaldehyde-binding protein (cRALBP) had not been described previously as autoantigen, but subsequent characterization in equine recurrent uveitis horses revealed B and T cell autoreactivity to this protein and established a link to epitope spreading. We further immunized healthy rats and horses with cRALBP and observed uveitis in both species with typical tissue lesions at cRALBP expression sites. The autoantibody profiling outlined here could be used in various autoimmune diseases to detect autoantigens involved in the dynamic spreading cascade or serve as predictive markers. © 2006 by The American Society for Biochemistry and Molecular Biology, Inc.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2006
HGF-reported in Year 0
ISSN (print) / ISBN 1535-9476
e-ISSN 1535-9484
Journal Molecular and Cellular Proteomics
Quellenangaben Volume: 5, Issue: 8, Pages: 1462-1470 Article Number: , Supplement: ,
Publisher American Society for Biochemistry and Molecular Biology
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
Research field(s) Genetics and Epidemiology
PSP Element(s) FE 70722
DOI 10.1074/mcp.M500352-MCP200
Scopus ID 33748287041
Erfassungsdatum 2006-11-14
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