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Thomae, A.W.* ; Schade, G.O.* ; Padeken, J.* ; Borath, M.* ; Vetter, I.* ; Kremmer, E. ; Heun, P.* ; Imhof, A.*

A pair of centromeric proteins mediates reproductive isolation in Drosophila species.

Dev. Cell 27, 412-424 (2013)
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Speciation involves the reproductive isolation of natural populations due to the sterility or lethality of their hybrids. However, the molecular basis of hybrid lethality and the evolutionary driving forces that provoke it remain largely elusive. The hybrid male rescue (Hmr) and the lethal hybrid rescue (Lhr) genes serve as a model to study speciation in Drosophilids because their interaction causes lethality in male hybrid offspring. Here, we show that HMR and LHR form a centromeric complex necessary for proper chromosome segregation. We find that the Hmr expression level is substantially higher in Drosophila melanogaster, whereas Lhr expression levels are increased in Drosophila simulans. The resulting elevated amount of HMR/LHR complex in hybrids results in an extensive mislocalization of the complex, an interference with the regulation of transposable elements, and an impairment of cell proliferation. Our findings provide evidence for a major role of centromere divergence in the generation of biodiversity.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Fission Yeast Centromere ; Dosage Compensation ; Heterochromatin Barrier ; Positive Selection ; Hybrid Sterility ; Speciation Gene ; Melanogaster ; Evolution ; Simulans ; Histone
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Journal Developmental Cell
Quellenangaben Volume: 27, Issue: 4, Pages: 412-424 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501793-001
PubMed ID 24239514
DOI 10.1016/j.devcel.2013.10.001
WOS ID WOS:000327812100007
Scopus ID 84888175603
Erfassungsdatum 2013-11-25
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