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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy.
Chem. Sci. 4, 3148-3153 (2013)
A series of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3,4-diamino-3-cyclobutene-1,2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170–176% enhancements in relaxation rate, following incubation with a neuronal cell line model. A derivative of the lead compound was prepared containing a biotin moiety, and both the specificity and reversibility of binding to the NMDA cell surface receptors demonstrated using confocal microscopy.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
2041-6520
e-ISSN
2041-6539
Journal
Chemical Science
Quellenangaben
Volume: 4,
Pages: 3148-3153
Publisher
Royal Society of Chemistry (RSC)
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)