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Biopersistent granular dust and chronic obstructive pulmonary disease: A systematic review and meta-analysis.
PLoS ONE 8:e80977 (2013)
OBJECTIVE: Applying a systematic review to identify studies eligible for meta-analysis of the association between occupational exposure to inorganic dust and the development of chronic obstructive pulmonary disease (COPD), and conducting a meta-analysis. DATA SOURCES: Searches of PubMed and Embase for the time period 1970-2010 yielded 257 cross-sectional and longitudinal studies on people exposed to inorganic dust at the workplace with data on lung function. These studies were independently abstracted and evaluated by two authors; any disagreement was resolved by a third reviewer. Of 55 publications accepted for meta-analysis, 27 investigated the effects of occupational exposure to biopersistent granular dust (bg-dust). METHODS: A random effects meta-analysis allowed us to provide an estimate of the average exposure effect on spirometric parameters presented in forest plots. Between-study heterogeneity was assessed by using I(2) statistics, with I(2)>25% indicating significant heterogeneity. Publication bias was investigated by visual inspection of funnel plots. The influence of individual studies was assessed by dropping the respective study before pooling study-specific estimates. RESULTS: The mean FEV1 of workers exposed to bg-dust was 160 ml lower or 5.7% less than predicted compared to workers with no/low exposure. The risk of an obstructive airway disease-defined as FEV1/FVC < 70%-increased by 7% per 1 mg· m(-3) respirable bg-dust. CONCLUSION: Occupational inhalative exposure to bg-dust was associated with a statistically significant decreased FEV1 and FEV1/FVC revealing airway obstruction consistent with COPD.
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Times Cited
Times Cited
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3.730
1.063
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15
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Publication type
Article: Journal article
Document type
Review
Keywords
Nutrition-examination-survey ; Air-flow Limitation ; African Gold Miners ; Lung-function ; Respiratory Symptoms ; Occupational-exposure ; Ventilatory Function ; General-population ; Norwegian Smelters ; Rubber Workers
Language
english
Publication Year
2013
HGF-reported in Year
2013
ISSN (print) / ISBN
1932-6203
Journal
PLoS ONE
Quellenangaben
Volume: 8,
Issue: 11,
Article Number: e80977
Publisher
Public Library of Science (PLoS)
Publishing Place
Lawrence, Kan.
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30503 - Chronic Diseases of the Lung and Allergies
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-503900-001
PubMed ID
24278358
WOS ID
WOS:000327313100131
Scopus ID
84894276571
Erfassungsdatum
2013-12-04