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Open Access Green as soon as Postprint is submitted to ZB.
Nuclear factor of activated T cells - a transcription factor family as critical regulator in lung and colon cancer.
Int. J. Cancer 134, 1767-1775 (2014)
Nuclear factor of activated T cells (NFAT) was first identified as a transcription factor which is activated upon T cell stimulation. Subsequent studies uncovered that a whole family of individual NFAT proteins exists with pleiotropic functions not only in immune but also in nonimmune cells. However, dysregulation of NFAT thereby favors malignant growth and cancer. Summarizing the recent advances in understanding how individual NFAT factors regulate the immune system, this review gives new insights into the critical role of NFAT in cancer development with special focus on inflammation-associated colorectal cancer.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Nuclear Factor of activated T celss; Cancer; Transcription factor; Colitis-associated Cancer; Factor Nfatc2 Controls; Nf-kappa-b; Pancreatic-cancer; Gene-expression; Cyclosporine-a; C-rel; Histone Acetylation; Signaling Pathway; Prostate-cancer
ISSN (print) / ISBN
0020-7136
e-ISSN
1097-0215
Journal
International Journal of Cancer
Quellenangaben
Volume: 134,
Issue: 8,
Pages: 1767-1775
Publisher
Wiley
Publishing Place
Hoboken
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes Research (IDF)
German Center for Diabetes Reseach (DZD)
German Center for Diabetes Reseach (DZD)