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Open Access Green as soon as Postprint is submitted to ZB.
Lunatic fringe promotes the lateral inhibition of neurogenesis.
Development 136, 2523-2533 (2009)
Previous studies have identified roles of the modulation of Notch activation by Fringe homologues in boundary formation and in regulating the differentiation of vertebrate thymocytes and Drosophila glial cells. We have investigated the role of Lunatic fringe (Lfng) expression during neurogenesis in the vertebrate neural tube. We find that in the zebrafish hindbrain, Lfng is expressed by progenitors in neurogenic regions and downregulated in cells that have initiated neuronal differentiation. Lfng is required cell autonomously in neural epithelial cells to limit the amount of neurogenesis and to maintain progenitors. By contrast, Lfng is not required for the role of Notch in interneuronal fate choice, which we show is mediated by Notch1a. The expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors. These findings suggest that Lfng acts in a feedback loop downstream of proneural genes, which, by promoting Notch activation, maintains the sensitivity of progenitors to lateral inhibition and thus limits further proneural upregulation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Lateral inhibition; Neurogenesis; Neural progenitors; Notch; Fringe; Zebrafish; dorsal-ventral boundary; apical ectodermal ridge; zebrafish hindbrain; neuronal differentiation; radical fringe; gene-expression; drosophila eye; nervous-system; notch pathway; danio-rerio
Language
Publication Year
2009
HGF-reported in Year
2009
ISSN (print) / ISBN
0950-1991
e-ISSN
1477-9129
Quellenangaben
Volume: 136,
Issue: 15,
Pages: 2523-2533
Publisher
Company of Biologists
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)
PSP Element(s)
G-550200-001
Scopus ID
69049118162
PubMed ID
19553285
Erfassungsdatum
2009-12-31