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Treutlein, G.* ; Deeg, C.A.* ; Hauck, S.M. ; Amann, B.* ; Hartmann, K.* ; Dorsch, R.*

Follow-up protein profiles in urine samples during the course of obstructive feline idiopathic cystitis.

Vet. J. 198, 625-630 (2013)

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Open Access Green as soon as Postprint is submitted to ZB.

Abstract
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Feline idiopathic cystitis (FIC) is a common lower urinary tract disorder in cats, which often recurs. Published reports document increased urine fibronectin and thioredoxin concentrations in cats with FIC compared with healthy control cats. Therefore, these proteins might be of interest in the pathophysiology of FIC. The purpose of the present study was to evaluate variations in these urine proteins throughout the course of FIC by assessing their concentrations in urine specimens from cats with a history of obstructive FIC. Urine total protein (TP) was measured using the Bradford assay, while urine fibronectin and thioredoxin concentrations were determined by Western blot analysis. Urine TP was significantly higher in cats with obstructive FIC at presentation (day 0) than in healthy control cats (P<0.01). There were significant decreases in urine TP in cats with obstructive FIC after 3months (P<0.01). Significantly higher urine fibronectin (P<0.01) and thioredoxin (P<0.05) concentrations were demonstrated in cats with FIC at day 0 compared to control cats, but there was no significant change over time (P>0.05). Increased concentrations of these proteins over time might reflect ongoing structural and pathological alterations to functional processes in the urinary bladders of cats with obstructive FIC.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cystitis; Feline lower urinary tract disease; Fibronectin; Thioredoxin; Urinary; Interstitial Cystitis; Tract Disease; Bladder-cancer; Risk-factors; Cats; Thioredoxin; Fibronectin; Injury; Pain; Mice

ISSN (print) / ISBN 1090-0233

e-ISSN 1532-2971

Journal Veterinary Journal, The

Quellenangaben Volume: 198, Issue: 3, Pages: 625-630

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CF Metabolomics & Proteomics (CF-MPC)