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Stefan, N. ; Häring, H.-U. ; Hu, F.B.* ; Schulze, M.B.

Metabolically healthy obesity: Epidemiology, mechanisms, and clinical implications.

Lancet Diabet. Endocrinol. 1, 152-162 (2013)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Obesity has become a worldwide epidemic that poses substantial health problems for both individuals and society. However, a proportion of obese individuals might not be at an increased risk for metabolic complications of obesity and, therefore, their phenotype can be referred to as metabolically healthy obesity. This novel concept of metabolically healthy obesity might become increasingly important to stratify individuals in the clinical treatment of obesity. However, no universally accepted criteria exist to define metabolically healthy obesity. Furthermore, many questions have been raised regarding the biological basis of this phenotype, the transitory nature of metabolically healthy obesity over time, and predictors of this phenotype. We describe the observational studies that gave rise to the idea of metabolically healthy obesity and the key parameters that can help to distinguish it from the general form of obesity. We also discuss potential biological mechanisms underlying metabolically healthy obesity and its public health and clinical implications.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Body-mass Index; Type-2 Diabetes-mellitus; Fatty Liver-disease; Middle-aged Men; Cardiovascular-disease; Insulin-resistance; Bariatric Surgery; Cardiorespiratory Fitness; Normal-weight; Adipose-tissue
Language english
Publication Year 2013
HGF-reported in Year 0
ISSN (print) / ISBN 2213-8587
e-ISSN 2213-8595
Journal Lancet Diabetes and Endocrinology
Quellenangaben Volume: 1, Issue: 2, Pages: 152-162 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-002
PubMed ID 24622321
DOI 10.1016/S2213-8587(13)70062-7
WOS ID WOS:000333768800024
Erfassungsdatum 2013-12-09
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