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Wen, W.* ; Cho, Y.S.* ; Zheng, W.* ; Dorajoo, R.* ; Kato, N.* ; Qi, L.* ; Chen, C.H.* ; Delahanty, R.J.* ; Okada, Y.* ; Tabara, Y.* ; Gu, D.* ; Zhu, D.* ; Haiman, C.A.* ; Mo, Z.* ; Gao, Y.T.* ; Saw, S.M.* ; Go, M.J.* ; Takeuchi, F.* ; Chang, L.C.* ; Kokubo, Y.* ; Liang, J.* ; Hao, M.* ; Le Marchand, L.* ; Zhang, Y.* ; Hu, Y.* ; Wong, T.Y.* ; Long, J.* ; Han, B.G.* ; Kubo, M.* ; Yamamoto, K.* ; Su, M.H.* ; Miki, T.* ; Henderson, B.E.* ; Song, H.* ; Tan, A.* ; He, J.* ; Ng, D.P.* ; Cai, Q.* ; Tsunoda, T.* ; Tsai, F.J.* ; Iwai, N.* ; Chen, G.K.* ; Shi, J.* ; Xu, J.* ; Sim, X.* ; Xiang, Y.B.* ; Maeda, S.* ; Ong, R.T.* ; Li, C.* ; Nakamura, Y.* ; Aung, T.* ; Kamatani, N.* ; Liu, J.J.* ; Lu, W.* ; Yokota, M.* ; Seielstad, M.* ; Fann, C.S.* ; GIANT Consortium (Heid, I.M. ; Thiering, E. ; Gieger, C. ; Grallert, H. ; Heinrich, J. ; Illig, T. ; Peters, A. ; Wichmann, H.-E.) ; Wu, J.Y.* ; Lee, J.Y.* ; Hu, F.B.* ; Tanaka, T.* ; Tai, E.S.* ; Shu, X.O.*

Meta-analysis identifies common variants associated with body mass index in east Asians.

Nat. Genet. 44, 307-311 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 × 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2012
HGF-reported in Year 2013
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 44, Issue: 3, Pages: 307-311 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Experimental Genetics (IEG)
Research Unit Molecular Epidemiology (AME)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
30201 - Metabolic Health
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504100-001
G-503900-001
G-521500-002
G-504000-001
G-504200-001
PubMed ID 22344219
DOI 10.1038/ng.1087
Erfassungsdatum 2013-12-11
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