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Müller, B. ; Hoeschen, C. ; Grüner, F.* ; Arkadiev, V.A.* ; Johnson, T.R.C.*

Molecular imaging based on X-ray fluorescent high-Z tracers.

Phys. Med. Biol. 58, 8063-8076 (2013)

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We propose a novel x-ray fluorescence imaging setup for the in vivo detection of high-Z tracer distributions. The main novel aspect is the use of an analyzer-based, energy-resolved detection method together with a radial, scatter reducing collimator. The aim of this work is to show the feasibility of this method by measuring the Bragg reflected K-fluorescence signal of an iodine solution sample in a proof of principle experiment and to estimate the potential of the complete imaging setup using a Monte Carlo simulation, including a quantification of the minimal detectable tracer concentration for in vivo imaging. The proof of principle experiment shows that even for a small detector area of approximately 7 mm(2), the collimated and Bragg reflected K-fluorescence signal of a sample containing an iodine solution with a concentration of 50 mu g ml(-1) can be detected. The Monte Carlo simulation also shows that the proposed x-ray fluorescence imaging setup has the potential to image distributions of high-Z tracers in vivo at a radiation dose of a few mGy and at tracer concentrations down to 1 mu g ml(-1) for iodine in small animals.

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