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Krähling, A.M.* ; Alvarez, L.* ; Debowski, K.* ; Van, Q.* ; Gunkel, M.* ; Irsen, S.* ; Al-Amoudi, A.* ; Strünker, T.* ; Kremmer, E. ; Krause, E.* ; Voigt, I.* ; Wörtge, S.* ; Waisman, A.* ; Weyand, I.* ; Seifert, R.* ; Kaupp, U.B.* ; Wachten, D.*

CRIS - a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending.

PLoS Genet. 9:e1003960 (2013)
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The second messengers cAMP and cGMP activate their target proteins by binding to a conserved cyclic nucleotide-binding domain (CNBD). Here, we identify and characterize an entirely novel CNBD-containing protein called CRIS (cyclic nucleotide receptor involved in sperm function) that is unrelated to any of the other members of this protein family. CRIS is exclusively expressed in sperm precursor cells. Cris-deficient male mice are either infertile due to a lack of sperm resulting from spermatogenic arrest, or subfertile due to impaired sperm motility. The motility defect is caused by altered Ca(2+) regulation of flagellar beat asymmetry, leading to a beating pattern that is reminiscent of sperm hyperactivation. Our results suggest that CRIS interacts during spermiogenesis with Ca(2+)-regulated proteins that-in mature sperm-are involved in flagellar bending.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Carboxy-terminal Region; Sperm Chemotaxis; Cyclic-amp; Tyrosine Phosphorylation; Intraflagellar Transport; Regulatory Subunit; Reduced Fertility; Mouse Spermatozoa; Structural Basis; Mammalian Sperm
Language english
Publication Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Journal PLoS Genetics
Quellenangaben Volume: 9, Issue: 12, Pages: , Article Number: e1003960 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place San Francisco
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-501793-001
PubMed ID 24339785
DOI 10.1371/journal.pgen.1003960
WOS ID WOS:000330533300010
Scopus ID 84892751544
Erfassungsdatum 2013-12-31
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