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Open Access Green as soon as Postprint is submitted to ZB.
Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.
OncoImmunology 2:e26199 (2013)
T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
T cell; CD8+ cytotoxic T cell; T cell receptor; Avidity; Koff rate
ISSN (print) / ISBN
2162-4011
e-ISSN
2162-402X
Journal
OncoImmunology
Quellenangaben
Volume: 2,
Issue: 10,
Article Number: e26199
Publisher
Taylor & Francis
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed