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Open Access Green as soon as Postprint is submitted to ZB.
Interaction between smoking and the interleukin-6 gene affects systemic levels of inflammatory biomarkers.
Nicotine Tob. Res. 11, 1347-1353 (2009)
Background: Smoking is associated with a systemic inflammatory response. However, the role of genetic predisposition is well known. We assessed whether circulatory acute phase reactants were associated with smoking and whether or not the association was modified by the major cytokine gene of the phase reaction, interleukin-6 (IL-6). Methods: in total, 1,003 postmyocardial infarction patients were recruited in six European cities and six repeated clinical examinations performed. C-reactive protein (CRP), interleukin 6 (IL-6), and fibrinogen, levels were assayed at 5,659 subject visits. Genotyping of single nucleotide polymorphisms was performed in the IL-6 gene. Results: Cumulative smoking (pack-years) and time since smoking cessation were strongly associated with blood levels of all three inflammatory markers. Among subjects any respiratory disorder, these associations remained statistically significant for CRP and IL-6. A polymorphism in the IL-6 gene (rs2069840) showed an interaction with on CRP (p < .001) and IL-6 (p = .049) peripheral levels. Conclusions: These results indicate a potential role of the IL-6 gene in the inflammatory response associated with smoking and suggest rs2069840 polymorphism deserves attention.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
c-reactive protein; myocardial-infarction survivors; cardiovascular risk-factors; cigarette-smoking; il-6 levels; population; markers; men; polymorphism; association
ISSN (print) / ISBN
1462-2203
e-ISSN
1469-994X
Journal
Nicotine & Tobacco Research
Quellenangaben
Volume: 11,
Issue: 11,
Pages: 1347-1353
Publisher
Oxford University Press
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)