Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Left-to-right asymmetry of aerosol deposition after shallow bolus inhalation depends on lung ventilation.
J. Aerosol Med. Pulm. Drug Deliv. 22, 333-339 (2009)
BACKGROUND: After shallow bolus inhalation of radiolabeled aerosols, gamma camera imaging has shown a left-right asymmetry, with a higher fraction of deposited particles in the left lung. It was not clear, however, whether this phenomenon was an effect of asymmetry in lung ventilation or aerosol deposition efficiency. METHODS: Lung ventilation and aerosol deposition was studied after shallow bolus inhalation and gamma camera imaging in nine healthy nonsmokers and 10 asymptomatic smokers. A 100-mL (81m)Kr-gas boli were administered within the Fowler and within the phase-1 dead space, respectively. In addition, 1-L full breaths of 81m-Kr-gas were inhaled. For aerosol deposition subjects inhaled 100-mL boli of 100-nm diameter radiolabeled carbon particles with shallow and deep penetration. Left-to-right (L/R) and central-to-peripheral (C/P) activity distribution of the lung was analyzed. RESULTS: None of the parameters analyzed were significantly different between nonsmokers and smokers. The full-breath 81m-Kr-gas inhalation revealed a similar activity distribution over the left and right lungs, according to their respective volumes (L/R ratio = 0.84 +/- 0.04; mean +/- SE). In contrast, the shallow bolus inhalation of 81m-Kr-gas to the phase-1 dead space revealed more activity in the left lung (L/R ratio = 1.49 +/- 0.15, normalized to full-breath Kr-gas L/R). This same left-right asymmetry was observed for the aerosol after shallow bolus inhalation (L/R ratio = 1.69 +/- 0.15), and there was no significant difference between Kr-gas and aerosol L/R ratio. C/P activity ratios of bolus inhalation to the phase-1 dead space were 1.71 +/- 0.19 and 1.79 +/- 0.15 (normalized to full-breath Kr-gas C/P) for gas and aerosol, respectively, and correlated with the L/R ratios. CONCLUSIONS: The data show that the asymmetry in shallow aerosol bolus deposition is primarily determined by lung ventilation. The reason for this asymmetry is unclear.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Aerosol Bolus Inhalation ; Airways ; Gamma Camera Imaging ; Left-right Asymmetry
ISSN (print) / ISBN
0894-2684
e-ISSN
1557-9026
Quellenangaben
Volume: 22,
Issue: 4,
Pages: 333-339
Publisher
Mary Ann Liebert
Publishing Place
New Rochelle, NY
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)