PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Siroux, V.* ; Gonzalez, J.R.* ; Bouzigon, E.* ; Curjuric, I.* ; Boudier, A.* ; Imboden, M.* ; Antò, J.M.* ; Gut, I.* ; Jarvis, D.* ; Lathrop, M* ; Omenaas, E.R.* ; Pin, I.* ; Wjst, M. ; Demenais, F.* ; Probst-Hensch, N.* ; Kogevinas, M.* ; Kauffmann, F.*

Genetic heterogeneity of asthma phenotypes identified by a clustering approach.

Eur. Respir. J. 43, 439-452 (2014)
Publ. Version/Full Text DOI PMC
Closed
Open Access Green as soon as Postprint is submitted to ZB.
The aim was to identify genetic variants associated with refined asthma phenotypes enabling to take into account multiple features of the disease.Latent class analysis (LCA) was applied in 3001 adults ever having asthma recruited in the frame of three epidemiological surveys (ECRHS, SAPALDIA, EGEA). Fourteen personal and phenotypic characteristics from questionnaires and clinical examination were used. A genome wide association study (GWAS) was conducted for each LCA-derived asthma phenotype, compared to subjects without asthma (n=3474).The LCA identified four adult asthma phenotypes, mainly characterized by the activity of the disease, the age of asthma onset and the atopic status. Associations of genome wide significance (<1.25×10-7) were observed between "active adult-onset non-allergic asthma" and rs9851461 flanking CD200 (3q13.2) and between "Inactive/mild non-allergic asthma" and rs2579931 flanking GRIK2 (6q16.3). Borderline significant results (2.5×10(-7).
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.355
2.411
20
44
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association; Childhood Asthma; Lung-function; Variants; Diseases; Risk; Loci; Susceptibility; Environment; Population
Language english
Publication Year 2014
Prepublished in Year 2013
HGF-reported in Year 2013
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 43, Issue: 2, Pages: 439-452 Article Number: , Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-003
PubMed ID 24311777
DOI 10.1183/09031936.00032713
WOS ID WOS:000330824500017
Scopus ID 84893454185
Erfassungsdatum 2013-12-31
[➜Report correction]