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Patient-reported outcomes in a survey of patients treated with oral antihyperglycaemic medications: Associations with hypoglycaemia and weight gain.
Diabetes Obes. Metab. 11, 1138-1144 (2009)
Aim To examine the association between medication side-effects (SEs) and patient-reported outcomes (PROs) among patients with type 2 diabetes treated with oral antihyperglycaemic agents (OAHAs). Methods A total of 1984 participants responded to an internet-based survey in the United States. Data were collected on hypoglycaemia 6 months and weight gain 12 months prior to the survey. Health-related quality of life (HRQoL) was measured using the EuroQol-5D (EQ-5D). Also administered were the Treatment Satisfaction Questionnaire for Medication v.1.4 (TSQM) and the Hypoglycaemia Fear Survey II (HFS). Results Symptoms of hypoglycaemia were reported by 62.9% of participants, and 36.9% reported weight gain. For those reporting hypoglycaemia, mean scores were lower for TSQM and EQ-5D and higher for HFS when compared with those with no symptoms (TSQM: 69.7 vs. 75.1; EQ-5D: 0.78 vs. 0.86; HFS: 17.5 vs. 6.2; all p < 0.0001). The same remained true when accounting for symptom severity, where severity was monotonically related with PRO scores (all p < 0.0001). Similarly, reported weight gain was associated with lower treatment satisfaction (69.0 vs. 73.3) and HRQoL (0.77 vs. 0.83), and increased fear of hypoglycaemia (15.7 vs. 11.8) (all p < 0.0001). In mixed linear regression analysis, the associations between medication SEs and PROs remained significant after adjusting for patient and disease characteristics. Conclusions Among patients with type 2 diabetes treated with OAHAs, self-reported hypoglycaemia and weight gain were associated with decreased treatment satisfaction and HRQoL. In addition, the presence of these SEs was associated with increased fear of hypoglycaemia.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
hypoglycaemia; oral antihyperglycaemic agents; patient-reported outcomes; type 2 diabetes; weight gain; type-2 diabetes-mellitus; treatment satisfaction; adherence; management; therapy; obesity; insulin; life; fear
ISSN (print) / ISBN
1462-8902
e-ISSN
1463-1326
Journal
Diabetes, Obesity and Metabolism
Quellenangaben
Volume: 11,
Issue: 12,
Pages: 1138-1144
Publisher
Wiley
Publishing Place
Malden
Non-patent literature
Publications
Reviewing status
Peer reviewed