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Open Access Green as soon as Postprint is submitted to ZB.
Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells.
FEBS Lett. 582, 3729-3733 (2008)
The transport protein particle (TRAPP) complex is required for proper vesicular transport from the ER to the Golgi. The composition of yeast TRAPP is well characterized, but the organization of mammalian TRAPP complex remains elusive. Using a tandem affinity purification (TAP) approach, we provide first experimental proof for the association of NIBP (NIK/IKKbeta binding protein) with Bet3 and find two human paralogs of Trs33 (A and B) associated with Bet3. Interaction studies and gel filtration analysis reveal that both proteins are part of human TRAPP and might mark two distinct isocomplexes that exert different functions in the regulation of ER-to-Golgi traffic.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Vesicular transport; TRAPP; Golgi; Bet3; Trs33
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Journal
FEBS Letters
Quellenangaben
Volume: 582,
Issue: 27,
Pages: 3729-3733
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Signaling and Translation (SAT)