Clues to quality of journals
Open Access Policy of Helmholtz Association 2016
CC Licencences
Publication Metrics
Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Statistics (last 5 years)
OA Publications
Submit Publication
Import publication from...
Report missing publication
Contact persons
Help
Text
Endnote (RIS)
BibTeX
DOI
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
CXCL16 is a surrogate marker of inflammatory bowel disease.
Scand. J. Gastroenterol. 43, 283-288 (2008)
Impaired barrier function of the gut and inadequate immunological response to intestinal pathogens are the cornerstones in the pathogenesis of inflammatory bowel disease (IBD). CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. The relevance of CXCL16 in IBD has so far been elusive. This objective of this study was to determine the association between CXCL16 and IBD. Material and methods. Soluble CXCL16 (sol-CXCL16) serum levels in a cohort of 239 patients with Crohn's disease were measured, 114 patients with ulcerative colitis and 144 controls. Results. In a univariate analysis, sol-CXCL16 was found to be markedly increased in patients with Crohn's disease or ulcerative colitis compared with that in controls (p<0.001). This was significantly associated with an increase of the inflammatory marker C-reactive protein (CRP) (p<0.01). In the multivariate analysis (adjusted for age, gender, body mass index (BMI), white blood cell (WBC) count, resistin and CRP) sol-CXCL16 was associated with Crohn's disease above versus below the median (OR 10.53 (3.97-27.78) p<0.001) and ulcerative colitis (OR 3.46 (1.40-8.55) p<0.01). Conclusion. Our findings suggest that CXCL16 may play a pro-inflammatory role in IBD, particularly Crohn's disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
1.758
0.810
19
24
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Crohn's disease; CXCL16; disease activity; inflammatory bowel disease; ulcerative colitis
Language
english
Publication Year
2008
HGF-reported in Year
2008
ISSN (print) / ISBN
0036-5521
e-ISSN
1502-7708
Quellenangaben
Volume: 43,
Issue: 3,
Pages: 283-288
Publisher
Informa Healthcare
Reviewing status
Peer reviewed
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-505300-001
Scopus ID
39049172656
Erfassungsdatum
2008-06-03