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Cutting edge: Memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function.
J. Immunol. 183, 6898-6902 (2009)
The size of the adaptive immune system is considered to be kept constant by the attrition of pre-existing memory. However, recently it was shown that the CD8 memory compartment can grow in size and the number of pre-existing memory is largely preserved, predicting that pre-existing immunity should be maintained (Vezys et al.; Nature 457: 196-199). Experimental proof for this assumption is still lacking. We address this question in the Listeria monocytogenes (L. m.) infection model and confirm the growth of size of the memory compartment by subsequent vaccination with modified vaccinia virus Ankara. We also find only modest attrition of pre-existing L.m.-specific memory CD8 T cells. However, preexisting protective immunity toward L.m. is not preserved. Pre-existing L.m.-specific effector-memory cells, in contrast to central memory cells, become altered, and this results in a significant loss of pre-existing protective immunity. Our findings are clinically relevant for vaccines introducing new CD memory cells in high numbers, as this might influence pre-existing immunity.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
vaccina virus ankara; listeeria-monocytogenes; interferon responses; lineage relationship; protective immunity; IL-7 receptor; effector; attrition; subsets; vaccination
ISSN (print) / ISBN
0022-1767
e-ISSN
1550-6606
Journal
Journal of Immunology
Quellenangaben
Volume: 183,
Issue: 11,
Pages: 6898-6902
Publisher
American Association of Immunologists
Non-patent literature
Publications
Reviewing status
Peer reviewed