PuSH - Publication Server of Helmholtz Zentrum München: Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus.

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Soerensen, A.B.* ; Lund, A.H.* ; Kunder, S. ; Quintanilla-Martinez, L. ; Schmidt, J. ; Wang, B.* ; Wabl, M.* ; Pedersen, F.S.*

Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus.

Retrovirol. 4:46 (2007)

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Mutations of an alternative splice donor site located within the gag region has previously been shown to broaden the pathogenic potential of the T-lymphomagenic gammaretrovirus Moloney murine leukemia virus, while the equivalent mutations in the erythroleukemia inducing Friend murine leukemia virus seem to have no influence on the disease-inducing potential of this virus. In the present study we investigate the splice pattern as well as the possible effects of mutating the alternative splice sites on the oncogenic properties of the B-lymphomagenic Akv murine leukemia virus.

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