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Bender, A.* ; Beckers, J. ; Schneider, I. ; Hölter, S.M. ; Haack, T.B.* ; Ruthsatz, T. ; Vogt Weisenhorn, D.M. ; Becker, L. ; Genius, J.* ; Rujescu, D.* ; Irmler, M. ; Mijalski, T. ; Mader, M.T. ; Quintanilla-Martinez, L. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Wurst, W. ; Schmid, J. ; Klopstock, T.

Creatine improves health and survival of mice.

Neurobiol. Aging 29, 1404-1411 (2008)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
The supplementation of creatine (Cr) has a marked neuroprotective effect in mouse models of neurodegenerative diseases. This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic, and anti-oxidant properties of Cr. As aging and neurodegeneration share pathophysiological pathways, we investigated the effect of oral Cr supplementation on aging in 162 aged C57Bl/6J mice. Outcome variables included "healthy" life span, neurobehavioral phenotyping, as well as morphology, biochemistry, and expression profiling from brain. The median healthy life span of Cr-fed mice was 9% higher than in control mice, and they performed significantly better in neurobehavioral tests. In brains of Cr-treated mice, there was a trend towards a reduction of reactive oxygen species and significantly lower accumulation of the "aging pigment" lipofuscin. Expression profiling showed an upregulation of genes implicated in neuronal growth, neuroprotection, and learning. These data show that Cr improves health and longevity in mice. Cr may be a promising food supplement to promote healthy human aging.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Creatine; Aging; Oxidative stress; Mitochondria; Lipofuscin; Life span
Language english
Publication Year 2008
HGF-reported in Year 2008
ISSN (print) / ISBN 0197-4580
e-ISSN 1558-1497
Journal Neurobiology of Aging
Quellenangaben Volume: 29, Issue: 9, Pages: 1404-1411 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place New York, NY [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
CF Comparative Medicine (AVM)
Institute of Developmental Genetics (IDG)
Institute of Pathology (PATH)
Institute of Stem Cell Research (ISF)
POF-Topic(s) 30201 - Metabolic Health

30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Genetics and Epidemiology

Enabling and Novel Technologies
Stem Cell and Neuroscience
PSP Element(s) G-500600-003
G-500900-002
G-500500-001
G-500300-001
G-500800-001
DOI 10.1016/j.neurobiolaging.2007.03.001
Scopus ID 47049092131
Erfassungsdatum 2008-08-28
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