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Open Access Green as soon as Postprint is submitted to ZB.
Creatine improves health and survival of mice.
Neurobiol. Aging 29, 1404-1411 (2008)
The supplementation of creatine (Cr) has a marked neuroprotective effect in mouse models of neurodegenerative diseases. This has been assigned to the known bioenergetic, anti-apoptotic, anti-excitotoxic, and anti-oxidant properties of Cr. As aging and neurodegeneration share pathophysiological pathways, we investigated the effect of oral Cr supplementation on aging in 162 aged C57Bl/6J mice. Outcome variables included "healthy" life span, neurobehavioral phenotyping, as well as morphology, biochemistry, and expression profiling from brain. The median healthy life span of Cr-fed mice was 9% higher than in control mice, and they performed significantly better in neurobehavioral tests. In brains of Cr-treated mice, there was a trend towards a reduction of reactive oxygen species and significantly lower accumulation of the "aging pigment" lipofuscin. Expression profiling showed an upregulation of genes implicated in neuronal growth, neuroprotection, and learning. These data show that Cr improves health and longevity in mice. Cr may be a promising food supplement to promote healthy human aging.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Creatine; Aging; Oxidative stress; Mitochondria; Lipofuscin; Life span
ISSN (print) / ISBN
0197-4580
e-ISSN
1558-1497
Journal
Neurobiology of Aging
Quellenangaben
Volume: 29,
Issue: 9,
Pages: 1404-1411
Publisher
Elsevier
Publishing Place
New York, NY [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed