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Andreansky, S.* ; Liu, H.* ; Adler, H. ; Koszinowski, U.H.* ; Efstathiou, S.* ; Doherty, P.C.*

The limits of protection by "memory" T cells in lg -/-mice persistently infected with a γ-herpesvirus.

Proc. Natl. Acad. Sci. U.S.A. 101, 2017-2022 (2004)
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Can CD4(+) and CD8(+) "memory" T cells that are generated and maintained in the context of low-level virus persistence protect, in the absence of antibody, against a repeat challenge with the same pathogen? Although immune T cells exert effective, long-term control of a persistent gamma-herpesvirus (gammaHV68) in Ig(-/-) microMT mice, subsequent exposure to a high dose of the same virus leads to further low-level replication in the lung. This lytic phase in the respiratory tract is dealt with effectively by the recall of memory T cells induced by a gammaHV68 recombinant (M3LacZ) that does not express the viral M3 chemokine binding protein. At least for the CD8(+) response, greater numbers of memory T cells confer enhanced protection in the M3LacZ-immune mice. However, neither WT gammaHV68 nor the minimally persistent M3LacZ primes the T cell response to the extent that a WT gammaHV68 challenge fails to establish latency in the microMT mice. Memory CD4(+) and CD8(+) T cells thus act together to limit gammaHV68 infection but are unable to provide absolute protection against a high-dose, homologous challenge.
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Publication type Article: Journal article
Document type Scientific Article
Keywords CHEMOKINE-BINDING-PROTEIN; BACTERIAL ARTIFICIAL CHROMOSOME; IN-VIVO; MURINE GAMMAHERPESVIRUS-68; CD4-DEFICIENT MICE; MEDIATED CONTROL; VIRUS-INFECTION; DEFICIENT MICE; B LYMPHOCYTES; VACCINATION
Language english
Publication Year 2004
HGF-reported in Year 2004
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 101, Issue: 7, Pages: 2017-2022 Article Number: , Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) CCG Hematopoetic Cell Transplants (IMI-KHZ)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-520300-001
PubMed ID 14764895
DOI 10.1073/pnas.0307320101
WOS ID 000189032600041
Scopus ID 1242319299
Erfassungsdatum 2004-02-09
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