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Adding fifth dimension to optoacoustic imaging: Volumetric time-resolved spectrally enriched tomography.
Light Sci. Appl. 3:e137 (2014)
Optoacoustics provides a unique set of capabilities for bioimaging, associated with the intrinsic combination of ultrasound- and light-related advantages, such as high spatial and temporal resolution as well as powerful spectrally enriched imaging contrast in biological tissues. We demonstrate here, for the first time, the acquisition, processing and visualization of five-dimensional optoacoustic data, thus offering unparallel imaging capacities among the current bioimaging modalities. The newly discovered performance is enabled by simultaneous volumetric detection and processing of multispectral data and is further showcased here by attaining time-resolved volumetric blood oxygenation maps in deep human vessels and real-time tracking of contrast agent distribution in a murine model in vivo.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
biophotonics; multispectral; optoacoustic imaging; photoacoustic tomography; In-vivo; Photoacoustic Microscopy; Computed-tomography; Carbon Nanotubes; Agents
ISSN (print) / ISBN
2047-7538
e-ISSN
2047-7538
Journal
Light: Science & Applications
Quellenangaben
Volume: 3,
Article Number: e137
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)