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Xapelli, S.* ; Agasse, F.* ; Grade, S. ; Bernardino, L.* ; Ribeiro, F.F.* ; Schitine, C.S.* ; Heimann, A.S.* ; Ferro, E.S.* ; Sebasti, A.M.* ; de Melo Reis, R.A.* ; Malva, J.O.*

Modulation of subventricular zone oligodendrogenesis: A role for hemopressin?

Front. Cell. Neurosci. 8:59 (2014)
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Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into all neural cell types of the central nervous system. In normal conditions, SVZ cells are poorly oligodendrogenic, nevertheless their oligodendrogenic potential is boosted following demyelination. Importantly, progressive restriction into the oligodendrocyte fate is specified by extrinsic and intrinsic factors, endocannabinoids being one of these factors. Although a role for endocannabinoids in oligodendrogenesis has already been foreseen, selective agonists and antagonists of cannabinoids receptors produce severe adverse side effects. Herein, we show that hemopressin (Hp), a modulator of CB1 receptors, increased oligodendroglial differentiation in SVZ neural stem/progenitor cell cultures derived from neonatal mice. The original results presented in this work suggest that Hp and derivates may be of potential interest for the development of future strategies to treat demyelinating diseases.
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Publication type Article: Journal article
Document type Scientific Article
Editors Gonzalez-Perez, O.*
Keywords Endocannabinoids ; Hemopressin ; Myelin Pathologies ; Oligodendrogenesis ; Subventricular Zone; Neural Stem-cells; Cb1 Cannabinoid Receptors; Progenitor Cells; Multiple-sclerosis; Endocannabinoid System; Glial Progenitors; Corpus-callosum; Precursor Cells; White-matter; Adult Brain
Language english
Publication Year 2014
HGF-reported in Year 2014
e-ISSN 1662-5102
Journal Frontiers in Cellular Neuroscience
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 59 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
PubMed ID 24578683
DOI 10.3389/fncel.2014.00059
WOS ID WOS:000332471100001
Erfassungsdatum 2014-03-02
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