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Standl, M. ; Demmelmair, H.* ; Koletzko, B.* ; Heinrich, J.

Cord blood LC-PUFA composition and allergic diseases during the first 10 yr. Results from the LISAplus study.

Pediatr. Allergy Immunol. 35, 344-350 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: It has been suggested that n-6 and n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) in blood are associated with risk of allergic diseases, although results are inconclusive. Low levels of n-6 LC-PUFA and high levels of n-3 LC-PUFA are anticipated to have beneficial effects. Pregnancy is considered a critical time period for imprinting the developing immune system. We examined whether n-6 LC-PUFA, n-3 LC-PUFA concentrations or the n-6/n-3 ratio in cord blood (CB) serum are associated with allergic diseases up to the age of 10 yr. METHODS: This analysis included 436 children from the Munich LISAplus birth cohort study. Information on doctor-diagnosed asthma, hay fever/allergic rhinitis, and eczema was collected using questionnaires completed at the ages 6 and 10 yr, and for eczema additionally at 2 yr. Specific immunoglobulin E (IgE) against inhalant allergens was measured at 6 and 10 yr. Fatty acid composition was measured by gas chromatography in serum from CB and from blood collected at 2, 6, and 10 yr. Associations between n-3, n-6 LC-PUFA concentrations, and the n-6/n-3 ratio in CB serum and allergic diseases or atopy were assessed using generalized estimating equations (GEE) considering the longitudinal structure. Models were adjusted for LC-PUFA concentrations at follow-up and potential confounding factors. RESULTS: There was no significant association between n-3 LC-PUFA, n-6 LC-PUFA, or the n-6/n-3 ratio in CB serum with eczema, asthma, hay fever/allergic rhinitis, or aeroallergen sensitization. CONCLUSIONS: There is no indication of a beneficial effect of increased n-3 LC-PUFA in CB serum on the development of any of the disease entities.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Allergies ; Asthma ; Atopy ; Children ; Cord Blood ; Eczema ; Epidemiology ; Fatty Acids ; Polyunsaturated Fatty Acids ; Rhinitis; Fish-oil Supplementation; Randomized Controlled-trial; Fatty-acids; High-risk; Immune-responses; Pregnancy; Infants; Age; Consumption; Outcomes
ISSN (print) / ISBN 0905-6157
e-ISSN 1399-3038
Journal Pediatric Allergy and Immunology
Quellenangaben Volume: 35, Issue: 4, Pages: 344-350 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)