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Work, M.E.* ; Reimers, L.L.* ; Quante, A.S. ; Crew, K.D.* ; Whiffen, A.* ; Terry, M.B.*

Changes in mammographic density over time in breast cancer cases and women at high risk for breast cancer.

Int. J. Cancer 135, 1740-1744 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
High mammographic breast density is one of the strongest intermediate markers of breast cancer risk, and decreases in density over time have been associated with decreases in breast cancer risk. Using repeated measures of mammographic density in a cohort of high-risk women, the Women at Risk (WAR) cohort at Columbia University Medical Center (N=2670), we examined whether changes in prediagnostic mammographic density differed among 85 prospectively-ascertained breast cancer cases and 85 age-matched controls, using a nested case-control design. Median age at first mammogram was 51 years (range, 29-77 years), with a median of 4 years between first and second prediagnostic mammogram (range, 1-15 years). Using linear regression with change in percent density as the outcome, we found that in women who did not go on to be diagnosed with breast cancer, change in percent density decreased as time between first and second mammogram increased (β=-1.62% per year, p=0.004). However, in women who did go on to be diagnosed with breast cancer, there was no overall change in percent density associated with time between first and second mammogram (β=0.29% per year, p=0.61); the change over time was statistically significantly different between cases versus controls (p <0.009). If replicated in larger cohorts, these results suggest that within-individual changes in mammographic density as measured by percent density may be a useful biomarker of breast cancer risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Breast Cancer ; Cancer Biomarker ; High-risk Cohort ; Mammographic Density; Nested Case-control; Family-history; United-states; Patterns; Population; Menopause; Tamoxifen; Features; Cohort; Age
ISSN (print) / ISBN 0020-7136
e-ISSN 1097-0215
Journal International Journal of Cancer
Quellenangaben Volume: 135, Issue: 7, Pages: 1740-1744 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)