PuSH - Publication Server of Helmholtz Zentrum München: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Beilina, A.* ; Rudenko, I.N.* ; Kaganovich, A.* ; Civiero, L.* ; Chau, H.* ; Kalia, S.K.* ; Kalia, L.V.* ; Lobbestael, E.* ; Chia, R.* ; Ndukwe, K.* ; Ding, J.* ; Nalls, M.A.* ; EUMODIC Consortium (Illig, T. ; Lichtner, P. ; *) ; Olszewski, M.* ; Hauser, D.N.* ; Kumaran, R.* ; Lozano, A.M.* ; Baekelandt, V.* ; Greene, L.E.* ; Taymans, J.-M.* ; Greggio, E.* ; Cookson, M.R.*

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Proc. Natl. Acad. Sci. U.S.A. 111, 2626-2631 (2014)

Publ. Version/Full Text Volltext

DOI

	Open Access Gold

Abstract
Metrics
Extra information

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD. Using protein–protein interaction arrays, we identified BCL2-associated athanogene 5, Rab7L1 (RAB7, member RAS oncogene family-like 1), and Cyclin-G–associated kinase as binding partners of LRRK2. The latter two genes are candidate genes for risk for sporadic PD identified by genome-wide association studies. These proteins form a complex that promotes clearance of Golgi-derived vesicles through the autophagy–lysosome system both in vitro and in vivo. We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

9.809

2.734

102

262