PuSH - Publication Server of Helmholtz Zentrum München: Impact of the adipokine adiponectin and the hepatokine fetuin-a on the development of type 2 diabetes: Prospective cohort- and cross-sectional phenotyping studies.

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Stefan, N. ; Sun, Q.* ; Fritsche, A. ; Machann, J. ; Schick, F.* ; Gerst, F. ; Jeppesen, C. ; Joost, H.G. ; Hu, F.B.* ; Boeing, H.* ; Ullrich, S. ; Häring, H.-U. ; Schulze, M.B.

Impact of the adipokine adiponectin and the hepatokine fetuin-a on the development of type 2 diabetes: Prospective cohort- and cross-sectional phenotyping studies.

PLoS ONE 9:e92238 (2014)

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BACKGROUND: Among adipokines and hepatokines, adiponectin and fetuin-A were consistently found to predict the incidence of type 2 diabetes, both by regulating insulin sensitivity. OBJECTIVE: To determine to what extent circulating adiponectin and fetuin-A are independently associated with incident type 2 diabetes in humans, and the major mechanisms involved. METHODS: Relationships with incident diabetes were tested in two cohort studies: within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study (628 cases) and the Nurses' Health Study (NHS; 470 cases). Relationships with body fat compartments, insulin sensitivity and insulin secretion were studied in the Tübingen Lifestyle Intervention Program (TULIP; N = 358). RESULTS: Circulating adiponectin and fetuin-A, independently of several confounders and of each other, associated with risk of diabetes in EPIC-Potsdam (RR for 1 SD: adiponectin: 0.45 [95% CI 0.37-0.54], fetuin-A: 1.18 [1.05-1.32]) and the NHS (0.51 [0.42-0.62], 1.35 [1.16-1.58]). Obesity measures considerably attenuated the association of adiponectin, but not of fetuin-A. Subjects with low adiponectin and concomitantly high fetuin-A had the highest risk. Whereas both proteins were independently (both p<1.8×10-7) associated with insulin sensitivity, circulating fetuin-A (r = -0.37, p = 0.0004), but not adiponectin, associated with insulin secretion in subjects with impaired glucose tolerance. CONCLUSIONS: We provide novel information that adiponectin and fetuin-A independently of each other associate with the diabetes risk. Furthermore, we suggest that they are involved in the development of type 2 diabetes via different mechanisms, possibly by mediating effects of their source tissues, expanded adipose tissue and nonalcoholic fatty liver.

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