PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Jastroch, M. ; Morin, S. ; Tschöp, M.H. ; Yi, C.-X.

The hypothalamic neural-glial network and the metabolic syndrome.

Best Pract. Res. Clin. Endocrinol. Metab. 28, 661-671 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Despite numerous educational interventions and biomedical research efforts, modern society continues to suffer from obesity and its associated metabolic diseases, such as type 2 diabetes mellitus, and these diseases show little sign of abating. One reason for this is an incomplete understanding of the pathology of the metabolic syndrome, which obstructs the development of effective therapeutic strategies. While hypothalamic neuropathy is a potential candidate that may contribute to the pathogenesis of the metabolic syndrome, the specific causes of hypothalamic neuropathy remain largely unknown. During different stages of high-calorie diet-induced metabolic syndrome, the hypothalamus undergoes gliosis and angiogenesis, both of which potentially reflect ongoing inflammatory processes. This overview discusses current data suggesting a role for hypothalamic inflammation-like processes in diet-induced metabolic diseases and provides a perspective on how to unravel molecular mechanisms of “hypothalamic inflammation” in order to develop anti-obesity therapeutic strategies.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.907
2.136
11
11
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Blood Brain Barrier ; Cytokines ; Diabetes ; Leptin Resistance ; Mitochondria ; Neurogenesis; Diet-induced Obesity; Blood-brain-barrier; Leptin Resistance; Energy-balance; Feeding-behavior; Neuropeptide-y; Knockout Mice; Body-weight; Fatty-acids; Paraventricular Nucleus
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1521-690X
e-ISSN 1532-1908
Journal Best Practice and Research Clinical Endocrinology and Metabolism
Quellenangaben Volume: 28, Issue: 5, Pages: 661-671 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502200-001
G-501900-221
PubMed ID 25256762
DOI 10.1016/j.beem.2014.02.002
WOS ID WOS:000343684300004
Erfassungsdatum 2014-03-28
[➜Report correction]