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Open Access Green as soon as Postprint is submitted to ZB.
The hypothalamic neural-glial network and the metabolic syndrome.
Best Pract. Res. Clin. Endocrinol. Metab. 28, 661-671 (2014)
Despite numerous educational interventions and biomedical research efforts, modern society continues to suffer from obesity and its associated metabolic diseases, such as type 2 diabetes mellitus, and these diseases show little sign of abating. One reason for this is an incomplete understanding of the pathology of the metabolic syndrome, which obstructs the development of effective therapeutic strategies. While hypothalamic neuropathy is a potential candidate that may contribute to the pathogenesis of the metabolic syndrome, the specific causes of hypothalamic neuropathy remain largely unknown. During different stages of high-calorie diet-induced metabolic syndrome, the hypothalamus undergoes gliosis and angiogenesis, both of which potentially reflect ongoing inflammatory processes. This overview discusses current data suggesting a role for hypothalamic inflammation-like processes in diet-induced metabolic diseases and provides a perspective on how to unravel molecular mechanisms of “hypothalamic inflammation” in order to develop anti-obesity therapeutic strategies.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Blood Brain Barrier ; Cytokines ; Diabetes ; Leptin Resistance ; Mitochondria ; Neurogenesis; Diet-induced Obesity; Blood-brain-barrier; Leptin Resistance; Energy-balance; Feeding-behavior; Neuropeptide-y; Knockout Mice; Body-weight; Fatty-acids; Paraventricular Nucleus
ISSN (print) / ISBN
1521-690X
e-ISSN
1532-1908
Quellenangaben
Volume: 28,
Issue: 5,
Pages: 661-671
Publisher
Elsevier
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)