Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques.
    
    
        
    
    
        
        Proc. SPIE 7899:789905 (2011)
    
    
    
      
      
	
	    In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.
	
	
	    
	
       
      
	
	    
		Impact Factor
		Scopus SNIP
		Web of Science
Times Cited
		Scopus
Cited By
		Altmetric
		
	     
	    
	 
       
      
     
    
        Publication type
        Article: Journal article
    
 
    
        Document type
        Scientific Article
    
 
    
        Thesis type
        
    
 
    
        Editors
        
    
    
        Keywords
        
    
 
    
        Keywords plus
        
    
 
    
    
        Language
        english
    
 
    
        Publication Year
        2011
    
 
    
        Prepublished in Year
        
    
 
    
        HGF-reported in Year
        0
    
 
    
    
        ISSN (print) / ISBN
        0277-786X
    
 
    
        e-ISSN
        1996-756X
    
 
    
        ISBN
        
    
    
        Book Volume Title
        
    
 
    
        Conference Title
        Photons Plus Ultrasound: Imaging and Sensing 2011
    
 
	
        Conference Date
        January 22, 2011
    
     
	
        Conference Location
        San Francisco, California, USA
    
 
	
        Proceedings Title
        
    
 
     
	
    
        Quellenangaben
        
	    Volume: 7899,  
	    Issue: ,  
	    Pages: ,  
	    Article Number: 789905 
	    Supplement: ,  
	
    
 
    
        
            Series
            
        
 
        
            Publisher
            SPIE
        
 
        
            Publishing Place
            
        
 
	
        
            Day of Oral Examination
            0000-00-00
        
 
        
            Advisor
            
        
 
        
            Referee
            
        
 
        
            Examiner
            
        
 
        
            Topic
            
        
 
	
        
            University
            
        
 
        
            University place
            
        
 
        
            Faculty
            
        
 
    
        
            Publication date
            0000-00-00
        
 
         
        
            Application date
            0000-00-00
        
 
        
            Patent owner
            
        
 
        
            Further owners
            
        
 
        
            Application country
            
        
 
        
            Patent priority
            
        
 
    
        Reviewing status
        Peer reviewed
    
 
     
    
        POF-Topic(s)
        30205 - Bioengineering and Digital Health
    
 
    
        Research field(s)
        Enabling and Novel Technologies
    
 
    
        PSP Element(s)
        G-505500-001
    
 
    
        Grants
        
    
 
    
        Copyright
        
    
 	
    
    
        Erfassungsdatum
        2011-12-31