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Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques.
Proc. SPIE 7899:789905 (2011)
Publ. Version/Full Text
DOI
In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Photons Plus Ultrasound: Imaging and Sensing 2011
Conference Date
January 22, 2011
Conference Location
San Francisco, California, USA
Journal
Proceedings of SPIE
Quellenangaben
Volume: 7899,
Article Number: 789905
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)