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Open Access Green as soon as Postprint is submitted to ZB.
Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution.
Laser Phys. Lett. 11:045601 (2014)
Conventional optoacoustic microscopy operates in two distinct modes of optical resolution, for visualization of superficial tissue layers, or acoustic resolution, intended for deep imaging in scattering tissues. Here we introduce a new microscope design with hybrid optical and acoustic resolution, which provides a smooth transition from optical resolution in superficial microscopic imaging to ultrasonic resolution when imaging at greater depths within intensely scattering tissue layers. Experimental validation of the new hybrid optoacoustic microscopy method was performed in phantoms and by means of transcranial mouse brain imaging in vivo.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Optoacoustic Imaging ; Optoacoustic Microscopy ; In Vivo Imaging ; Transcranial Imaging ; Hybrid Focusing; In-vivo; Photoacoustic Microscopy
ISSN (print) / ISBN
1612-2011
Journal
Laser Physics Letters
Quellenangaben
Volume: 11,
Issue: 4,
Article Number: 045601
Publisher
Wiley
Publishing Place
Berlin
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)