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Weigert, C. ; Lehmann, R. ; Hartwig, S.* ; Lehr, S.*

The secretome of the working human skeletal muscle - a promising opportunity to combat the metabolic disaster?

Proteomics Clin. Appl. 8, 5-18 (2014)

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Open Access Green as soon as Postprint is submitted to ZB.

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Recent years have provided clear evidence for the skeletal muscle as an endocrine organ. Muscle contraction during physical activity has emerged as an important activator of the release of the proteins and peptides called myokines." Diverse proteomic profiling approaches were applied to rodent and human skeletal muscle cells to characterize the complete secretome, to study the regulation of the secretome during cell differentiation or the release of myokines upon contractile activity of myotubes. Several of the exercise-regulated factors have the potency to mediate an interorgan crosstalk. The paracrine function of the secreted peptides and proteins to regulate muscle regeneration, tissue remodeling, and trainability can have direct effects on whole-body glucose disposal and oxygen consumption. The overall composition and dynamic of the myokinome are still incompletely characterized. Recent advantages in metabolomics and lipidomics will add metabolites and lipids with autocrine, paracrine, or endocrine function to the contraction-induced secretome of the skeletal muscle. The identification of these metabolites will lead to a more comprehensive view described by a new myo(metabo)kinome consisting of peptides, proteins, and metabolites.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Exercise ; Muscle ; Myometabokinome ; Myokine; L6 Myotube Secretome; Cancer-cell Line; Physical-activity; Proteomic Analysis; Mass-spectrometry; In-vitro; 2-dimensional Electrophoresis; Gel-electrophoresis; Insulin-secretion; Endocrine Organ

ISSN (print) / ISBN 1862-8346

e-ISSN 1862-8354

Journal Proteomics - Clinical Applications

Quellenangaben Volume: 8, Issue: 1-2, Pages: 5-18

Publisher Wiley

Publishing Place Weinheim

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)