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Open Access Green as soon as Postprint is submitted to ZB.
Classification of mass-spectrometric data in clinical proteomics using learning vector quantization methods.
Brief. Bioinform. 9, 129-143 (2008)
In the present contribution we propose two recently developed classification algorithms for the analysis of mass-spectrometric data-the supervised neural gas and the fuzzy-labeled self-organizing map. The algorithms are inherently regularizing, which is recommended, for these spectral data because of its high dimensionality and the sparseness for specific problems. The algorithms are both prototype-based such that the principle of characteristic representants is realized. This leads to an easy interpretation of the generated classifcation model. Further, the fuzzy-labeled self-organizing map is able to process uncertainty in data, and classification results can be obtained as fuzzy decisions. Moreover, this fuzzy classification together with the property of topographic mapping offers the possibility of class similarity detection, which can be used for class visualization. We demonstrate the power of both methods for two exemplary examples: the classification of bacteria (listeria types) and neoplastic and non-neoplastic cell populations in breast cancer tissue sections.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
classification; vector quantization; class visualization; machine learning; fuzzy-labeled self-organizing map; mass spectrometry
ISSN (print) / ISBN
1467-5463
e-ISSN
1477-4054
Journal
Briefings in Bioinformatics
Quellenangaben
Volume: 9,
Issue: 2,
Pages: 129-143
Publisher
Oxford University Press
Non-patent literature
Publications
Reviewing status
Peer reviewed