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Open Access Green as soon as Postprint is submitted to ZB.
A mother's influence on metabolic disorders.
J. Nat. Med. 20, 244-245 (2014)
Human epidemiological studies have revealed that maternal obesity predisposes offspring to metabolic disorders, though little is known about the mechanism that causes this phenomenon. In a step forward, Vogt et al. have shown in mice that the offspring of mothers fed a high-fat diet during lactation show an alteration in the number of projections in nerves in the hypothalamus in the brain and in the pancreas. These offspring are predisposed to be obese and develop diabetes, and the mechanism by which these connections are altered seems to be through insulin signaling. Here we asked three experts what the implications of these findings might be to humans.
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Publication type
Article: Journal article
Document type
Editorial
Keywords
Hypothalamic Neurons; Leptin; Circuits; Diet
Language
english
Publication Year
2014
HGF-reported in Year
0
ISSN (print) / ISBN
1340-3443
e-ISSN
1861-0293
Journal
Journal of natural medicines
Quellenangaben
Volume: 20,
Issue: 3,
Pages: 244-245
Publisher
Springer
Publishing Place
Tokyo [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502200-001
WOS ID
WOS:000332595600016
Erfassungsdatum
2014-04-14